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Valacyclovir is an antiviral drug. It slows the growth and spread of the herpes virus to help the body fight the infection. Valacyclovir is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles (herpes zoster) in adults. Valacyclovir is used to treat cold sores in children who are at least 12 years old, or chickenpox in children who are at least 2 years old.
Cheapest pharmacy for valacyclovir at $3 per tablet.
And, there are plenty of reasons to think it will change that.
"I think that one of the main drivers to lowering price of valacyclovir is the pressure that it's gotten," says Daniel Stolter, a senior counsel at the Cochrane Drug Guide Centre. "I think there is a view that the price is a little too high. People are using more than they need. We've seen the use of valacyclovir being diverted to non-HIV therapies."
Lack of awareness the risk
Stolter says that lack of awareness the risk getting infected with HIV, particularly in HIV-infected men, has meant that the drug been over-prescribed – which means that the cost of valacyclovir has skyrocketed.
In the US, an estimated 6 million people in 2014 were taking antiretroviral therapy, and estimates suggest that there may be up to 1.8 million new cases of HIV each year in the US alone. "And number of people with HIV in the US is rapidly increasing and growing at almost four to five times of what it was in the 1990s," Stolter notes.
"I think, from a public health standpoint, the price of valacyclovir is really one the more difficult items that has changed dramatically in the last few years," he says.
There are other barriers. One of the biggest is that many of the patients taking valacyclovir have high levels of the drug on a per-pill basis. Stolter says that some people are taking the drug as a prophylactic or maintenance drug that they can just keep on doing. If they are that level of valacyclovir, then a lower price per pill would be more likely to help reduce the rate of their infection.
To lower the price, you have to think of your individual situation
Another obstacle is that the US drug approval process is complicated. Stolter says that manufacturers have to go through several phases prove the safety of their product before it's approved for a new indication. This is difficult in the developing world where many regulators lack the experience in reviewing drugs countries like the US and China.
But it's also a barrier for generics manufacturers who are still learning how to produce drugs. For instance, in the US, all of other ingredients inside a valacyclovir tablet are made by the manufacturer. But they just don't make sure that there aren't any dangerous allergens or toxins that could enter into their manufacturing process. "You have to think of your individual situation and if you can get to someplace else where there are more resources, then that would be really valuable," says Stolter. (For example, if you live in a developing country, generic manufacturers may be your best bet.)
There's also a price incentive to cut prices because if you come to the US and just use generic equivalent of valacyclovir for 10 years,.
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FDA approved on May 2, 2011
Indications and Usage for Valacyclovir Hepatitis C infection
Valacyclovir is indicated for the treatment of patients with mild to moderate hepatic encephalopathy who meet the following conditions:
Less than 25 years of age
Cases of symptomatic hepatitis C at any time during the past two years (i.e. have not been cured by treatment with a cure-inactive regimen)
The drug should be started as soon possible after the physician discovers initial signs and symptoms of liver disease not later than at 15 or 30 days.
The drug should be started 30 days to one week after successful completion of hepatitis C antiviral therapy or, in an in-patient setting, when the patient is not receiving antiviral therapy for the first time because virus may have become undetectable during antiviral treatment.
Patients should be considered for therapy when they have:
Evidence of chronic viral replication
No antiviral treatment documented
Liver disease has been confirmed on enzyme-immunoassay, serum creatinine level (ICD) cheapest price for valacyclovir and viral RNA PCR tests is clinically confirmed via the criteria described in current list of diagnostic criteria for viral hepatitis [See Cautions (4.1)].
Patients should be managed in accordance with state and local clinical guidelines for the treatment of chronic hepatitis C; use antiviral drugs for the treatment of other illnesses is cheapest price for valacyclovir encouraged.
Patients should be observed for a minimum of four weeks and periodically monitored for relapse. Failure to observe patients for a minimum of two weeks following treatment may indicate an increased likelihood of progression or recurrence the disease.
The drug can be discontinued at any time without signs of toxicity.
Possible hepatotoxicity should be investigated by appropriate procedures (see PRECAUTIONS (5.1).
The recommended dosage of valacyclovir valacyclovir generic for sale is 1000 mg orally three times daily (3x/d) administered after meals at a dose of 100 mg each. This daily dosage should be increased to 1000 mg three times daily if the patient is intolerant to other antiparasitic drugs.
Fluctuations in or abnormal liver enzymes, jaundice, jaundice or elevated hepatic enzymes on standard biochemical tests should be accompanied by a clinical evaluation or treatment by a liver specialist. with valacyclovir may prolong the duration of symptoms or worsen them. Patients should be treated with caution if, despite supportive therapy, jaundice persists for longer than seven days.
Hepatitis C virus-infected patients should be closely monitored Amitriptyline 10mg uk
for symptoms and signs of hepatitis virus infection as a means for detecting acute or chronic viral hepatitis. In such cases, an antiviral treatment should be.
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